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KMID : 0616120070380040372
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Korean Journal of Pharmacognosy
2007 Volume.38 No. 4 p.372 ~ p.375
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Antioxidant Effect of Alisma plantago-aquatica var. orientale and Its Main Component
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Kim Se-Eun
Ryu Dong-Young
Takako Yokozawa
Park Jong-Cheol
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Abstract
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Reactive oxygen species(ROS) or free radicals are produced in the pathogenesis of human diseases including atherosclerosis, diabetes, cancer, and aging. Antioxidants are associated with the prevention of ROS-induced tissue and cellular damage in the various diseases. This study investigated the antioxidative activities of the methanol extract of Alisma plantagoaquatica var. orientale and its main component under conditions of radical generation using allophycocyanin and ferric-thiocyanate assay. Alisol B 23-acetate as a main component was isolated from the methanol extract of Alisma plantago-aquatica var. orientale. In results, the extract of Alisma plantago-aquatica var. orientale showed inhibitory activity on AAPH [2,2’-azobis(2-amidinopropane)dihydrochloride]-induced protein oxidation. Also, the extract of Alisma plantago-aquatica var. orientale and alisol B 23-acetate inhibited lipid peroxidation. These results indicate that Alisma plantago-aquatica var. orientale and alisol B 23-acetate show promise as therapeutic agents for various damages involving free radical reactions.
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KEYWORD
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reactive oxygen species, free radical, Alisma plantago-aquatica var. orientale, alisol B 23-acetate, antioxidant
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